Zoobiquity Morning Case Presentations
Arthur H. Rubenstein Auditorium, Smilow Center for Translational Research,
Perelman School of Medicine, University of Pennsylvania,
3400 Civic Center Boulevard, Philadelphia, PA
Atopic Dermatitis and the Cutaneous Microbiome
- Elizabeth Grice, PhD, Assistant Professor, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania
- Charles Bradley, VMD, Lecturer, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania
- Jennifer Gardner, MD, Assistant Professor of Dermatology, University of Washington School of Medicine
- Atopic dermatitis with secondary staphylococcal folliculitis in a three-year-old female spayed French bulldog
- Atopic dermatitis with secondary cutaneous staphylococcal overgrowth in a three-year-old girl
Drs. Grice and Bradley, along with their team of collaborators from the disciplines of dermatology, microbiology, and pathology, study the role of the cutaneous microbiome in the pathogenesis of atopic dermatitis (AD) in dogs. Canine AD is a spontaneously occurring homologue of human AD, and offers great promise as a model for translational studies.
Dr. Gardner will present the case of atopic dermatitis in a young girl to illustrate the clinical correlates with veterinary patients. By better defining how targeted antimicrobial therapy influences microbial communities and the resistome of atopic patients, the Penn team hopes to model new therapeutic targets for people and their pets.
Sleep Apnea Causes and Pharmacotherapies
- Joan Hendricks, VMD, PhD, the Gilbert S. Kahn Dean, School of Veterinary Medicine, University of Pennsylvania
- Sigrid Veasey, MD, PhD, Professor, Department of Medicine, Perelman School of Medicine, University of Pennsylvania
• Restless sleep and daytime hypersomnolence in a two-year-old male English bulldog
• Hypersomnolence, loud snoring, and obesity in a 40-year-old man
Veterinarians recognized that a dangerously small airway in the English bulldog resulted in obstructed breathing and snoring. As early as the 1920s, a surgical procedure was developed by veterinarians to open up the airway. Remarkably, this disorder in humans was not considered until half a century later, when a similar procedure was developed for humans to treat obstructive sleep apnea. Dr. Hendricks collaborated with Dr. Veasey to determine the causes of airway obstruction and to explore pharmacotherapies to treat both dogs and humans with sleep apnea.
- Nicola Mason, BVetMed, PhD, Associate Professor of Medicine and Pathobiology, School of Veterinary Medicine, University of Pennsylvania
- Kristy Weber, MD, Professor, Department of Orthopaedic Surgery; Director of the Sarcoma Program, Abramson Cancer Center; Chief of Orthopaedic Oncology
- Induction and effect of anti-tumor immunity in a nine-year-old, male castrated Labrador with osteosarcoma
- Left distal femoral osteosarcoma with eventual metastatic disease to the lung in an eight-year-old boy
Osteosarcoma is an aggressive mesenchymal tumor of bone that affects children in their first and second decades of life. Treatment consists of intensive chemotherapy and removal of the primary tumor, either through amputation or limb-sparing surgery. Despite these measures, 30% of children develop metastatic disease and die within five years of diagnosis.
Dogs develop osteosarcoma that shares similar clinical, biological, genetic, and therapeutic features to that in children, and is a well-recognized model for pediatric osteosarcoma. There have been no major advances in the treatment and outcomes of osteosarcoma in children or dogs for over 20 years. Dr. Weber will present a case of pediatric osteosarcoma and outline the major challenges faced for effective therapy. Dr. Mason will present a case of canine osteosarcoma where use of a recombinant bacterial vaccine was able to induce anti-tumor immunity and prevent metastatic disease.